Benzylpenicillin procaine
- Form: Liquid for injection.
- Pharmacological properties: Benzylpenicillin procaine belongs to the group of beta-lactam antibiotics, has a bactericidal effect on gram-positive bacteria, including Clostridium spp., Corynebacterium spp., Erysipelothrix spp., Enterococcus spp., Listeria spp., Staphylococcus spp., Streptococcus spp.. The action of the substance is based on the suppression of the activity of peptidoglycan synthesis enzymes, which leads to the cessation of bacterial growth, and also activates enzymes that hydrolyze peptidoglycan, which weakens the covalent bonds of the cell wall. Growing cells stop dividing, increase, swell and disintegrate with the formation of small particles. The features of procaine benzylpenicillin are slow absorption. The components of the drug penetrate into most organs and tissues, reaching maximum concentrations in blood serum after 30-90 minutes, and remain in the body in therapeutic concentrations for at least 24 hours. The drug is excreted from the body mainly with urine and bile, and in lactating animals - partially with milk.
- Storage conditions: Dry, dark and cool room with a temperature regime from 5°C to 25°C.
- Packaging and storage: Bottles of 10, 100 and 250 ml. Shelf life is 2-3 years from the date of manufacture.
Effectiveness of application: The drug is used to treat animals with the following infectious diseases:
- Respiratory tract diseases (pneumonia, bronchopneumonia, atrophic rhinitis);
- Diseases of the genitourinary system (cystitis, pyelonephritis);
- Diseases of the gastrointestinal tract (enteritis, gastroenteritis);
- Sepsis;
- Peritonitis;
- Purulent infections of the skin and soft tissues (abscess, phlegmon);
- Postpartum infections, mastitis;
- Secondary bacterial infections.
Application standards: The drug is administered intramuscularly once a day for 3-5 days. Cattle, sheep, pigs, horses 1 ml per 25 kg of body weight, but not more than 10 ml in one place.
Overdose: It is important to follow the instructions for use.
Special precautions: The drug is not recommended for use in females in the last third of pregnancy. Cattle should be slaughtered for meat no earlier than 21 days after the last administration of the drug, pigs after 18 days, and sheep after 30 days.
Special precautions for personnel: Wear protective clothing when administering the drug. Be sure to wash your hands thoroughly before and after the procedure. It is important to follow safety precautions when administering the drug to animals under the skin.
Forms of incompatibility: Simultaneous or sequential use with other ototoxic and nephrotoxic drugs (neomycin, kanamycin, gentamicin) is not allowed.
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